# 1st author, * corresponding author, Lab members
MOR, GPCR, H. sapiens
S Khan, AS Tyson, M Ranjbar, Z Zhang, J Singh, GW Han, Gati C*
Structural snapshots capture nucleotide release at the mu-opioid receptor.
Nature. 2025. in press.
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MOR, GPCR, H. sapiens
L Posa#, G Romano#, X Ji#, S Khan#, AL Nazarova#, SS Moshtaghin, B Paz, GW Han, AJ Gonzalez-Hernandez, A Arefin, I Srivastava, SA Zaidi, M Ranjbar, K Pleil, K Pande, V Katritch*, C Gati*, D Trauner*, J Levitz*
An opioid efficacy switch for reversible optical control of peripheral analgesia.
bioRxiv. 2025.
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GAT3, SLC, H. sapiens
R Yadav, GW Han, C Gati*
Molecular basis of human GABA transporter 3 inhibition.
Nature Communications. 2025.
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KOR, GPCR, H. sapiens
A Tyson, S Khan, Z Motiwala, GW Han, Z Zhang, M Ranjbar, D Styrpejko, N Ramos-Gonzalez, S Woo, K Villers, D Landaker, T Kenakin, R Shenvi, S Majumdar and C Gati*
Molecular mechanisms of inverse agonism via kappa-opioid receptor-G protein complexes
Nature Chemical Biology. 2025.
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C3aR / C5aR1, GPCR, H. sapiens
M K Yadav#, J Maharana#, R Yadav#, S Saha#, P Sarma, C Soni, V Singh, S Saha, M Ganguly, XX Li, S Mahapatra, S Mishra, HA Khant, M Chami, TM Woodruff, R Banerjee*, AK Shukla* and C Gati*
Molecular basis of anaphylatoxin recognition, activation, and signaling-bias at complement receptors.
Cell. 2023.
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GAT1, SLC, H. sapiens
Z Motiwala, NG Aduri, H Shaye, GW Han, JH Lam, V Katritch, V Cherezov, C Gati*
Structural basis of GABA reuptake inhibition.
Nature. 2022.
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Fzd5, GPCR, H. sapiens
N Tsutsumi, S Mukherjee, D Waghray, CY Janda, KM Jude, Y Miao, JS Burg, NG Aduri, AA Kossiakoff, C Gati*, KC Garcia*
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling.
eLife. 2020.
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GABA(B), GPCR, H. sapiens
H Shaye, A Ishchenko, JH Lam, GW Han, L Xue, P Rondard, JP Pin, V Katritch, C Gati*, V Cherezov*
Structural basis of the activation of a metabotropic GABA receptor.
Nature. 2020.
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